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TGF-β1 induces epithelial-mesenchymal transition and fibrosis of ureteral epithelial cells via targeting RACK1 in ureteropelvic junction obstruction

   
@article{TP153063,
	author = {Wenyou Chen and Fengguang Ye and Xiaoqiang Lin and Jinrong Chen and Fengbin Yang and Yanhui Wang and Songbin Lin and Weicheng Huang and Ziwei Jian and Chaoming Zhou},
	title = {TGF-β1 induces epithelial-mesenchymal transition and fibrosis of ureteral epithelial cells via targeting RACK1 in ureteropelvic junction obstruction},
	journal = {Translational Pediatrics},
	volume = {15},
	number = {4},
	year = {2026},
	keywords = {},
	abstract = {Ureteropelvic junction obstruction (UPJO) is a frequent cause of congenital hydronephrosis. It involves both structural and functional changes at the ureteropelvic junction (UPJ), where the ureter connects with the renal pelvis. The mechanisms behind tissue remodeling and fibrosis in this condition are not fully understood. This study explores the role of epithelial-mesenchymal transition (EMT) and examines how receptor for activated C kinase 1 (RACK1) may regulate this process in UPJO.},
	issn = {2224-4344},	url = {https://tp.amegroups.org/article/view/153063}
}