@article{TP153969,
author = {Xiaopeng Zhang and Xu Dong and Donggang Yao and Yuanyuan Wei and Jinfeng Qi and Tongtong Jin and Dunhui Fan and Haiya Bai},
title = {Efficacy and safety of oral propranolol combined with intralesional injection of lauromacrogol for infantile hemangioma: a systematic review and meta-analysis},
journal = {Translational Pediatrics},
volume = {15},
number = {6},
year = {2026},
keywords = {},
abstract = {Background: XXXXXXXXXXXXXX. This study aimed to identify the efficacy and safety of oral propranolol (PRO) combined with intralesional injection of lauromacrogol (LAU) for infantile hemangioma (IH) by comparison with PRO or LAU monotherapy.Methods: PubMed, Web of Science, Chinese National Knowledge Infrastructure and VIP databases were searched up to April 23, 2026. Endpoints of efficacy included the cure rate (reduction in size >75%), significant rate (reduction in size >50%), effective rate (reduction in size >25%) and treatment time. The incidence of adverse reactions was investigated to evaluate the safety.Results: Eight available studies were included, with four randomized controlled trials (RCTS) and four retrospective studies. A total of 668 patients were enrolled, among whom 318 patients were in the PRO + LAU group. By comparison with patients in the PRO group, patients in the PRO + LAU group revealed higher cure rate [odds ratio (OR) =3.22, 95% confidence interval (CI): 1.40–7.41, P=0.006], significant effective rate (OR =3.61, 95% CI: 1.94–6.74, P},
issn = {2224-4344}, url = {https://tp.amegroups.org/article/view/153969}
}