@article{TP155974,
author = {Shuhui Wang and Xuan Tang and Jin Ma and Nana Wang and Yan Wang and Yang Gao and Hongbiao Huang and Guanghui Qian and Jiaying Zhang and Haitao Lv and Xuan Li},
title = {FOS regulation of T-cell activation and the mechanism of inflammatory injury of coronary endothelium in Kawasaki disease},
journal = {Translational Pediatrics},
volume = {15},
number = {6},
year = {2026},
keywords = {},
abstract = {Background: Kawasaki disease (KD) is a pediatric systemic vasculitis often causing coronary lesions driven by aberrant T-cell activation. While FOS modulates T cells, its specific function in KD remains undefined. This study aims to investigate the role of FOS in T-cell activation and coronary endothelial inflammation in KD.Methods: The study integrated transcriptomic profiling of T cells from patients with KD and a murine model of Candida albicans cell wall extract (CAWS)-induced vasculitis to characterize FOS expression and vasculitis. Mechanistically, we employed lentiviral modulation of FOS in activated JURKAT cells co-cultured with human coronary artery endothelial cells (HCAECs) to delineate the impact of FOS on T-cell activation and endothelial inflammation.Results: Compared to controls, FOS expression was significantly upregulated in peripheral blood T cells of acute KD patients (P},
issn = {2224-4344}, url = {https://tp.amegroups.org/article/view/155974}
}