@article{TP155996,
author = {Ping Hong and Yueming Wu and Jing Qiu and Lei Lei and Lu Gan and Bin Cai and Yu Gao and Fei Jie and Shiyan Cao and Lin Zhou},
title = {Novel inflammatory biomarkers and disease severity in hospitalized children with Mycoplasma pneumoniae pneumonia: a retrospective study},
journal = {Translational Pediatrics},
volume = {15},
number = {6},
year = {2026},
keywords = {},
abstract = {Background: A resurgence of Mycoplasma pneumoniae (M. pneumoniae) infections has been observed worldwide, including large outbreaks in China during 2023–2024, with a higher incidence of severe and complicated pneumonia cases. Identifying clinical and laboratory indicators associated with disease severity may assist clinicians in early risk stratification. This study aimed to explore the association between novel inflammatory biomarkers and disease severity in hospitalized children with M. pneumoniae pneumonia (MPP).Methods: We conducted a retrospective analysis of 866 hospitalized children with MPP. For each case, we calculated the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Multivariable logistic regression analysis was performed to identify factors associated with severe MPP. Receiver operating characteristic (ROC) curves were used to evaluate the discriminatory performance of these biomarkers for distinguishing severe cases from non-severe MPP.Results: Compared with the non-severe group, children with severe MPP showed significantly higher levels of NLR, PLR, and SII (all P},
issn = {2224-4344}, url = {https://tp.amegroups.org/article/view/155996}
}