@article{TP20638,
author = {Catherine Deshaies and Nancy Poirier and Paul Khairy},
title = {An evidence-based standardized protocol for anticoagulation following congenital heart surgery},
journal = {Translational Pediatrics},
volume = {7},
number = {4},
year = {2018},
keywords = {},
abstract = {Unfractionated heparin is the cornerstone of prevention and treatment of thrombosis in children undergoing cardiac surgery due to its short half-life and reversibility using protamine. Yet, optimal titration in children remains challenging (1). Age-related differences in heparin clearance (2), protein binding activity (3,4) and anti-thrombin concentration (5-8), which are most pronounced in neonates and young infants, obscure the applicability of standard adult dosing protocols.},
issn = {2224-4344}, url = {https://tp.amegroups.org/article/view/20638}
}