@article{TP25002,
author = {Florian Zeck and Heiko Reutter},
title = {Gastrointestinal diseases among relatives of patients with esophageal atresia with or without tracheoesophageal fistula},
journal = {Translational Pediatrics},
volume = {8},
number = {5},
year = {2019},
keywords = {},
abstract = {Background: Several studies have identified genetic factors that are associated with the formation of isolated and non-isolated esophageal atresia with or without tracheoesophageal fistula (EA/TEF) in human and mice. Some of these genetic factors like FOXF1/Foxf1 are associated with Barrett syndrome, esophageal carcinoma or tumors of the gastrointestinal tract. Here, we investigated the prevalence of common gastrointestinal diseases among EA/TEF patients and their first- and second-degree relatives (parents and grandparents).
Methods: We send out a questionnaire to 280 EA/TEF families asking for the presence of Barrett syndrome, Achalasia and carcinoma of the esophagus, the stomach, the small and large intestine among first- and second-degree relatives.
Results: In 32 of 124 families we found at least one affected family member with a possible association of colon carcinoma and the occurrence of EA/TEF within the same family.
Conclusions: Further studies are needed to evaluate a possible association.},
issn = {2224-4344}, url = {https://tp.amegroups.org/article/view/25002}
}