TY  - JOUR
AU  - Zeck, Florian
AU  - Reutter, Heiko
PY  - 2019
TI  - Gastrointestinal diseases among relatives of patients with esophageal atresia with or without tracheoesophageal fistula
JF  - Translational Pediatrics; Vol 8, No 5 (December 20, 2019): Translational Pediatrics
Y2  - 2019
KW  - 
N2  - Background: Several studies have identified genetic factors that are associated with the formation of isolated and non-isolated esophageal atresia with or without tracheoesophageal fistula (EA/TEF) in human and mice. Some of these genetic factors like FOXF1/Foxf1 are associated with Barrett syndrome, esophageal carcinoma or tumors of the gastrointestinal tract. Here, we investigated the prevalence of common gastrointestinal diseases among EA/TEF patients and their first- and second-degree relatives (parents and grandparents).   Methods: We send out a questionnaire to 280 EA/TEF families asking for the presence of Barrett syndrome, Achalasia and carcinoma of the esophagus, the stomach, the small and large intestine among first- and second-degree relatives.   Results: In 32 of 124 families we found at least one affected family member with a possible association of colon carcinoma and the occurrence of EA/TEF within the same family.   Conclusions: Further studies are needed to evaluate a possible association.
UR  - https://tp.amegroups.org/article/view/25002