The issue of Translational Pediatrics (TP) presents eight articles from Giessen & Frankfurt, Germany and Vienna, Austria representing the wide spectrum of pediatric cardiology. The aim of the authors is to exchange knowledge with the worldwide pediatric community in current topics of cardio-vascular diseases in children and adolescents by publishing their articles in TP as an open access. The authors are convinced, that the articles find the interest of the readers of TP, but not only of pediatric cardiologists, surgeons, anesthesiologists, intensivists, but even pediatricians and neonatologists, all responsible for improving further the care of young patients with cardiovascular disease.