Weekly pegylated recombinant human growth hormone for prepubertal children with growth hormone deficiency: adherence advantage drives superior short-term efficacy over daily rhGH

Pediatric growth hormone deficiency (GHD) causes growth retardation due to insufficient pituitary growth hormone (GH) secretion. Conventional daily recombinant human growth hormone (rhGH) has low adherence due to frequent injections, impairing efficacy; weekly pegylated recombinant human growth hormone (PEG-rhGH) may improve adherence, but the mediating role of adherence differences in efficacy remains unclear. This study aimed to XXXXXXXXXXXXXXXXXXXXXXX.