Title: Magic Microbial World and Amazing Laboratory Technology

Cover story: April marks a peak season for respiratory tract infections among primary school students, characterized by a significant prevalence of Mycoplasma infections. Mycoplasma pneumonia presents with non-specific symptoms, including high fever, cough, and sputum, mirroring those of influenza, COVID-19, and various atypical viral infections. During this period, we experienced high fever and sought treatment at the Shanghai Children’s Medical Center (SCMC). Initially, our condition was suspected to be Mycoplasma infection; however, tests for related antibodies and RNA yielded negative results. Empirical treatment with azithromycin proved ineffective. Subsequently, we were referred to the precision diagnosis and treatment department, which utilized rapid molecular diagnostic technology to identify the influenza virus in samples from our nasal cavity and throat. Following targeted treatment with oseltamivir, our symptoms improved, allowing us to return to school. While at the SCMC, we visited the National Key Laboratory of Precision Medicine, learning about various diagnostic methods for infectious diseases, such as culture, staining, smearing, DNA, protein, and antigen-antibody testing. We are fascinated by microbiology and admire the technicians operating precision testing instruments. We extend our heartfelt thanks to Professors Cao Qing, Shen Nan, Chen Wenjuan, and Tao Yue for their meticulous care and treatment. We are committed to diligently studying and mastering these techniques to become proficient infectious disease doctors in the future.

Artist: Ze-hao Yu, aged 10, and You-en Yu, aged 7, brothers residing in Shanghai. Their interests include reading, drawing, model construction, and outdoor exploration. Additionally, they have a keen interest in microorganisms and dinosaurs. Last year, they jointly received the Children’s Technology Invention Award. Throughout the flu season, they continued their studies and reading. Their preferred literary work is The Adventures of Tintin.